KCNJ16 (NP_061128, 319 a.a. ~ 416 a.a) partial recombinant protein with GST tag. The sequence is KYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVRESCTSDTKARRRSFSAVA IVSSCENPEETTTSATHEYRETPYQKALLTLNRISVES
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene.
Pathway
Activation of G protein gated Potassium channels; G protein gated Potassium channels; GABA receptor activation; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Citations
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