IPNV is a single-shelled, non-enveloped virus that belongs to the family Birnaviridae. Its genoma comprises a bisegmented double-stranded RNA, the segment B encodes VP1 and the segment A yields a polyprotein, pVP2-VP4-VP3 and a small protein (VP5) dispensable for viral replication. The polyprotein is autocatalytically cleaved by the endoprotease VP4 to release the structural proteins pVP2 (62 kDa) and VP3. pVP2 is processed during virus maturation into VP2 (54 kDa) constituting the outer capsid component. IPNV is responsible for infectious pancreatic necrosis, a contagious fish disease characterized by severe damage to the internal organs and tissues with a high mortality among salmonids. Infectious pancreatic necrosis (IPN) is a severe viral disease of salmonid fish. It is caused by Infectious Pancreatic Necrosis Virus, which is a member of the birnaviridae family. This disease mainly affects young salmonids, such as trout or salmon, of less than 6 months, although adult fish may carry the virus without showing symptoms. Resistance to infection develops more rapidly in warmer water. It is highly contagious and found worldwide, however some regions have managed to eradicate or greatly reduced the incidence of disease. The disease is normally spread horizontally via infected water but spread also occurs vertically. It is not a zoonosis.