Anti-IgG1 monoclonal antibody [Biotin] (CABT-49912MR)

Mouse anti-Rat IgG1 monoclonal antibody for ELISA. Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
MARG1-2
Species Reactivity
Rat
Immunogen
Rat IR27 IgG1 myeloma protein
Conjugate
Biotin

Target


Alternative Names
Ig gamma 1 chain C region; IGHG1; Immunoglobulin heavy constant gamma 1 (G1m marker); IgG1; Immunoglobulin G1; IgG1 hinge region
Entrez Gene ID
UniProt ID
P20759

Product Background


Pathway
Classical antibody-mediated complement activation; Complement cascade; Creation of C4 and C2 activators; FCGR activation; Fcgamma receptor (FCGR) dependent phagocytosis; Immune System; Initial triggering of complement;

Citations


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References


Stickler, MM; Reddy, A; et al. The human G1m1 allotype associates with CD4+T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site. GENES AND IMMUNITY 12:213-221(2011).
Magdelaine-Beuzelin, C; Vermeire, S; et al. IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab. PHARMACOGENETICS AND GENOMICS 19:383-387(2009).

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