Anti-ITGA4 (internal region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to an internal domain of human CD49d – conjugated to KLH.

Conjugate

Application Notes

Immunohistology - Paraffin: 10ug/ml

Alternative Names

ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); IA4; CD49D; integrin alpha-4; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D

Entrez Gene ID

UniProt ID

Antigen Description

CD49d is a ~150kDa single pass type 1 transmembrane glycoprotein with seven FG-GAP repeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa. CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form The Peyer patches-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue through its interaction with MadCam-1, preferentially expressed on Peyer's patch high endothelial venules and postcapillary venules in lamina propria .VLA-4 is expressed on lymphocytes, monocytes, mast cells, macrophages, basophils and eosinophils, and has key roles in inflammation, cellular adhesion and cellular activation. LPAM-1 is expressed mainly on lymphocytes, and plays a key role in lymphocyte recruitment to sites of inflammation.