This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Pathway
Activated NOTCH1 Transmits Signal to the Nucleus; Adaptive Immune System; Antigen processing: Ubiquitination and Proteasome degradation; CXCR4-mediated signaling events; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Class I MHC mediated antigen processing and presentation; Delta-Notch Signaling Pathway; Disease
Citations
Publication ()
Have you cited DPAB-L20609 in a publication? Let us know and earn a reward for your research.
My Review for Anti-ITCH (N-terminal) polyclonal antibody
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Publication 
Loading ......
