Anti-IPO8 (aa 1026-1037) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: SAFNFGTVPSNN, corresponding to C terminal amino acids 1026-1037 of Human Importin 8.

Conjugate

Application Notes

IHC-P: 4 - 6 μg/ml

Alternative Names

IPO8; importin 8; RANBP8; importin-8; imp8; RAN binding protein 8; ran-binding protein 8;

Entrez Gene ID

UniProt ID

Antigen Description

Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.