Anti-INO80B polyclonal antibody (DPABH-11457)

Rabbit anti-Human INO80B (aa 153-182) polyclonal antibody for FC, WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide within Human INO80B aa 153-182 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9C086
Conjugate
Unconjugated

Applications


Application Notes
Flow Cyt: 1/10 - 1/50; WB: 1/100 - 1/500;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
INO80B; INO80 complex subunit B; IES2; hIes2; PAPA-1; ZNHIT4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
INO80B (INO80 Complex Subunit B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is INO80B-WBP1. This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript.
Antigen Description
Induces growth and cell cycle arrests at the G1 phase of the cell cycle. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. The function about INO80B antigen include metal ion binding; protein binding.

Citations


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References


Park, JH; Park, EJ; et al. Mammalian SWI/SNF chromatin remodeling complexes are required to prevent apoptosis after DNA damage. DNA REPAIR 8:29-39(2009).
Bao, YH; Shen, XT; et al. INO80 subfamily of chromatin remodeling complexes. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 618:18-29(2007).

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