Specifications
Immunogen
INADL (NP_733750, 545 a.a. ~ 651 a.a) partial recombinant protein with GST tag. The sequence is TLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDEL LEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRR
Target
Alternative Names
INADL; InaD-like (Drosophila); Cipp; PATJ; hINADL; InaD-like; inaD-like protein; PDZ domain protein; protein associated to tight junctions; channel-interacting PDZ domain protein; PALS1-associated tight junction protein; inactivation no after-potential D-
Product Background
Antigen Description
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.
Pathway
Cell junction organization; Cell-cell junction organization; Hippo signaling pathway; Tight junction
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Lemmers, C; Medina, E; et al. hINADI/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. JOURNAL OF BIOLOGICAL CHEMISTRY 277:25408-25415(2002).
Philipp, S; Flockerzi, V; et al. Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster. FEBS LETTERS 413:243-248(1997).
COA
Certificate of Analysis
