Anti-IL6RA polyclonal antibody (DPABY-270)

Goat Anti-Mouse IL6RA polyclonal antibody for WB, FC, IHC, ELISA(Cap), Neut Datasheet

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Specifications


Host Species
Goat
Antibody Isotype
IgG
Species Reactivity
Mouse
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IL-6 R alpha . Leu20-Glu357 Accession Number P22272
Conjugate
Unconjugated

Applications


Application Notes
Western Blot 0.1 μg/mL; Flow Cytometry 2.5 μg/106 cells; Immunohistochemistry 5-15 μg/mL; ELISA Capture 0.2-0.8 μg/mL; ELISA Detection 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DPABY-270 - DPABY-569
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
IL6RA; interleukin 6 receptor, alpha; Il6r; CD126; IL-6R; interleukin-6 receptor subunit alpha
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include multicentric castleman disease and castleman disease. Among its related pathways are Signaling by GPCR and IL6-mediated signaling events. GO annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is IL11RA. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Antigen Description
View IL-6 R alpha IHC images. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
Pathway
Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction; HIF-1 signaling pathway; Hematopoietic cell lineage; IL-6 signaling Pathway; Immune System; Interleukin-6 signaling; Iron Homeostasis.

Citations


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References


Pham, D; Walline, CC; et al. The Transcription Factor Twist1 Limits T Helper 17 and T Follicular Helper Cell Development by Repressing the Gene Encoding the Interleukin-6 Receptor alpha Chain. JOURNAL OF BIOLOGICAL CHEMISTRY 288:27423-27433(2013).

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