Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide corresponding to residues at the C-terminal of Human IL1RA antagonist.
Applications
Application Notes
WB: 1/10000 - 1/50000; IP: 1/10 - 1/100; IHC-P: 1/100 - 1/250; Flow Cyt: 1/10 - 1/100; ICC/IF: 1/250 - 1/500; IHC-Fr: 1/200;
Target
Alternative Names
IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3);
Product Background
Antigen Description
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Pathway
Cytokine Signaling in Immune system, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin-1 signaling, organism-specific biosystem; Signaling by Interleukins, organism-specific biosystem;
Citations
Publication ()
Have you cited DCABH-1695 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
