Specifications
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human ST2/IL-1 R4. Lys19-Phe328 Accession Number BAA02233
Applications
Application Notes
Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-3957 - DPABY-438
Target
Alternative Names
IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R; interleukin-1 receptor-like 1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed;
Product Background
Antigen Description
The Interleukin 1 receptor family comprises at least nine members. All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor) signaling domain that is also conserved in the Toll-like receptor family. A subtype of the IL-1 R family, SIGIRR (single Ig domain-containing IL-1 R-related molecule) differs from the other nine members by having only one Ig domain. ST2L, also known as IL-1 R4, is a transmembrane glycoprotein in the interleukin-1 receptor family. ST2L is expressed on mast cells and Th2 cells as well as on stressed cardiac myocytes and airway epithelia. ST2L associates with IL-1R AcP to form a receptor complex for IL-33. Alternative splicing generates ST2, a secreted isoform that functions as an inhibitor of IL-33 signaling. Within the ECD, mouse ST2L shares 68% aa sequence identity with human ST2L.
Citations
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Houghton-Trivino, N; Salgado, DM; et al. Levels of soluble ST2 in serum associated with severity of dengue due to tumour necrosis factor alpha stimulation. JOURNAL OF GENERAL VIROLOGY 91:697-706(2010).
Saito, T; Ji, G; et al. Genetic variations in humans associated with differences in the course of hepatitis C. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317:335-341(2004).
COA
Certificate of Analysis
