Anti-IL17RD monoclonal antibody (DCABH-0008CL)

Specifications


Host Species
Rat
Antibody Isotype
IgG2a
Species Reactivity
N/A
Immunogen
IL17RD / SEF antibody was raised against nS0-derived rmIL-17 RD. (aa 28 - 299).
Conjugate
Unconjugated

Applications


Application Notes
IHC - Frozen (5 - 25 μg/ml)
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
IL17RD; interleukin 17 receptor D; interleukin-17 receptor D; FLJ35755; IL 17RD; IL17RLM
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IL17RD (Interleukin 17 Receptor D) is a Protein Coding gene. Diseases associated with IL17RD include hypogonadotropic hypogonadism 18 with or without anosmia and kallmann syndrome. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RB. This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms.
Antigen Description
Hypogonadotropic hypogonadism 18 with or without anosmia (HH18) [MIM:615267]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in IL17RD also have a heterozygous mutation in another HH-associated gene including FGFR1 and KISS1R (PubMed:23643382). The function about IL17RD antigen include receptor activity.
Pathway
FGF signaling pathway, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by FGFR, organism-specific biosystem.

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References


HERMANN, P; BLANCHARD, D; et al. EXPRESSION OF A 32-KDA LIGAND FOR THE CD40 ANTIGEN ON ACTIVATED HUMAN T-LYMPHOCYTES. EUROPEAN JOURNAL OF IMMUNOLOGY 23:961-964(1993).
Oreffo, ROC; Kusec, V; et al. Expression of estrogen receptor-alpha in cells of the osteoclastic lineage. HISTOCHEMISTRY AND CELL BIOLOGY 111:125-133(1999).

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