Anti-IL17D monoclonal antibody, clone 357003

Antibody Isotype

IgG2b

Clone

357003

Species Reactivity

Human

Immunogen

E. coli-derived recombinant human IL-17D. Ala18-Pro202 Accession Number Q8TAD2.1

Conjugate

Application Notes

Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4096 - DPABY-685

Alternative Names

IL17D; interleukin 17D; IL27; IL-27; IL-17D; interleukin-17D; interleukin 27;

Entrez Gene ID

UniProt ID

Antigen Description

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Pathway

IL17 signaling pathway;