Anti-IGFALS monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human IGFALS is used for rabbit immunization.

Conjugate

Alternative Names

IGFALS; insulin-like growth factor binding protein, acid labile subunit; insulin-like growth factor-binding protein complex acid labile subunit; ALS; insulin-like growth factor binding protein complex acid labile chain;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.

Pathway

Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem;