Full length protein corresponding to Human IFNAR1 aa 1-557. (NP_000620).Sequence: MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWN RSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEI KLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGT KDSVMWALDGLSFTYSLVIW
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Pathway
Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction; Downstream signaling in naive CD8+ T cells; Hepatitis C; Herpes simplex infection;
Citations
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