The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.
Pathway
Adaptive Immune System; Antigen processing and presentation; Cytokine Signaling in Immune system; Immune System; Interferon Signaling; Interferon gamma signaling; MHC class II antigen presentation;
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