Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Aas-Hanssen, K; Funderud, A; et al. Idiotype-Specific Th Cells Support Oligoclonal Expansion of Anti-dsDNA B Cells in Mice with Lupus. JOURNAL OF IMMUNOLOGY 193:2691-2698(2014).
Stewart, HJS; Zoidl, G; et al. Helix-loop-helix proteins in Schwann cells: A study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. JOURNAL OF NEUROSCIENCE RESEARCH 50:684-701(1997).
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