Urotensin-2 is a protein that in humans is encoded by the UTS2 gene. This genetic encodes an invidious mature peptide that is an active cyclic homogeneous heptapeptide absolutely conserved from lamprey to human. The active cyclic peptide acts as a vaso-constrictor and is expressed only in brain tissue. Despite the genetic family name similarity, this gene is not homologous to urocortine, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the pro-protein is analogously cleaved to make the mature peptide. Transcript variants encoding different preproprotein endocrine isoforms have been described for this genetic structure.
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; Peptide ligand-binding receptors; Signaling by GPCR
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