Anti-Transcription Factor AP2-Beta monoclonal antibody (DMAB8503)

Mouse anti-Human Transcription Factor AP2-Beta monoclonal antibody for ELISA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG
Clone
4H6-2E12
Species Reactivity
Human
Immunogen
Recombinant human AP2-beta (amino acids 12-460) with GST tag.
Conjugate
Unconjugated

Target


Alternative Names
AP-2B; AP2-B
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TFAP2B (Transcription Factor AP-2 Beta) is a Protein Coding gene. Diseases associated with TFAP2B include char syndrome and patent ductus arteriosus. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is TFAP2E. This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
Antigen Description
AP2-beta is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes during early development. AP-2 factors bind to the consensus sequence 5"-GCCNNNGGC-3" and activate genes involved in large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes. AP2-beta appears to be required for normal face and limb development and for proper termnal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. It can form homodimers or heterodimers with other AP-2 family members. Defects in AP2-beta are the cause of Char syndrome (CHAR) which is characterised by patent ductus anteriosus (PDA), facial dysmorphism and hand anomalies. Char syndrome (CHAR) [MIM:169100]: An autosomal dominant disorder characterized by patent ductus arteriosus (PDA), facial dysmorphism and hand anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry. Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene. AP-2 beta is a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor.

Citations


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References


Jin, Y; Norquay, LD; et al. Binding of AP-2 and ETS-domain family members is associated with enhancer activity in the hypersensitive site III region of the human growth hormone/chorionic somatomammotropin locus. MOLECULAR ENDOCRINOLOGY 18:574-587(2004).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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