Specifications
Immunogen
Recombinant human TGF beta Receptor II extracellular domain
Applications
Application Notes
ICC/IF 1/50; WB 1/100 - 1/1000; Flow Cyt: 1μg/106 cells; IHC-P: 1/50 - 1/200.
Target
Alternative Names
TGFBR2; transforming growth factor, beta receptor II (70/80kDa); MFS2,transforming growth factor, beta receptor II (70 80kD); TGF-beta receptor type-2; AAT 3; AAT3; FAA 3; FAA3; HNPCC6; MFS 2; MFS2; RIIC; TAAD 2; TAAD2; TbetaR II; TGF beta receptor type 2
Product Background
Antigen Description
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Pathway
ALK1 signaling events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Cytokine-cytokine receptor interac
Citations
Publication ()
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COA
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