Anti-T-Cell Receptor V beta-7 monoclonal antibody (DMAB4370MH)

Mouse anti-Human T-Cell Receptor V beta-7 monoclonal antibody for FC Datasheet

Bring this labeled antibody directly to your bench!

Online Inquiry Add to basket

Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
AOE1
Species Reactivity
Human
Immunogen
Murine T-cell hybridoma transfected with V-beta-7 gene segment.
Conjugate
Unconjugated

Target


Alternative Names
TRB@; T cell receptor beta locus; TRB; TCRB; T-cell receptor, beta cluster; T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
Entrez Gene ID

Product Background


Gene summary
TRB (T Cell Receptor Beta Locus) is a Protein Coding gene. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas.
Pathway
Cytokines andInflammatory Response; T Cell Receptor Signaling Pathway.

Citations


Have you cited DMAB4370MH in a publication? Let us know and earn a reward for your research.

References


Clapp, TR; Stone, LM; et al. Immunocytochemical evidence for co-expression of Type III IP(3) receptor with signaling components of bitter taste transduction. BMC NEUROSCIENCE 2:-(2001).
Schmidt-Eisenlohr, H; Rittig, M; et al. Biomonitoring of pJP4-carrying Pseudomonas chlororaphis with Trb protein-specific antisera. ENVIRONMENTAL MICROBIOLOGY 3:720-730(2001).

Related Products


Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-T-Cell Receptor V beta-7 monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket