Anti-T-Cell Receptor V beta-7 monoclonal antibody (DMAB4370MH)

Mouse anti-Human T-Cell Receptor V beta-7 monoclonal antibody for FC Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Murine T-cell hybridoma transfected with V-beta-7 gene segment.


Alternative Names
TRB@; T cell receptor beta locus; TRB; TCRB; T-cell receptor, beta cluster; T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
Entrez Gene ID

Product Background

Gene summary
TRB (T Cell Receptor Beta Locus) is a Protein Coding gene. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas.
Cytokines andInflammatory Response; T Cell Receptor Signaling Pathway.


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Peng, FC; Chen, PC; et al. Metabolism of territrem B and C in liver microsomes from 14-wk-old Wistar rats is catalyzed by cytochrome P-450 3A. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 68:299-314(2005).
Clapp, TR; Stone, LM; et al. Immunocytochemical evidence for co-expression of Type III IP(3) receptor with signaling components of bitter taste transduction. BMC NEUROSCIENCE 2:-(2001).

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