Anti-SGOL1 monoclonal antibody (CABT-28601MH)

Mouse anti-Human SGOL1 monoclonal antibody for ICC/IF, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
EML2116
Species Reactivity
Human
Immunogen
Recombinant full length protein, corresponding to amino acids 1-293 of Human Shugoshin
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 - 5 μg/ml; ICC/IF: 1/200; Flow Cyt: 0; 5μg/106 cells.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SGOL1; shugoshin-like 1 (S. pombe); shugoshin-like 1; hSgo 1; hSgo1; NY BR 85
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SGO1 (Shugoshin 1) is a Protein Coding gene. Diseases associated with SGO1 include chronic atrial and intestinal dysrhythmia and sick sinus syndrome. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
Antigen Description
Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene. Chronic atrial and intestinal dysrhythmia (CAID) [MIM:616201]: A disease characterized by dysregulation of the cardiac sinus node resulting in sick sinus syndrome, in association with chronic intestinal pseudo-obstruction, a disorder of gastrointestinal motility in which intestinal obstruction occurs in the absence of a mechanical obstacle. Note=The disease is caused by mutations affecting the gene represented in this entry. Shugoshin-like 1 is a protein that in humans is encoded by the SGOL1 gene. 0The function about SGOL1 antigen include protein binding.
Pathway
Aurora B signaling, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem; Mitotic Prometaphase, organism-specific biosystem; Oocyte meiosis, organism-specific biosystem; Oocyte meiosis, conserved biosystem; PLK1 signaling events, organism-specific biosystem.

Citations


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References


Kim, MS; An, CH; et al. Frameshift mutations of chromosome cohesion-related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability. HUMAN PATHOLOGY 44:2234-2240(2013).
Cohen, Y; Gutwein, O; et al. The proliferation arrest of primary tumor cells out-of-niche is associated with widespread downregulation of mitotic and transcriptional genes. HEMATOLOGY 19:286-292(2014).

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