Anti-SERPINI1 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Highly pure (#98%) recombinant Human Neuroserpin.

Conjugate

Application Notes

Sandwich ELISA: 0.5 - 2μg/ml; WB: 0.1 - 0.2μg/ml; Indirect ELISA: 0.5 - 2μg/m

Alternative Names

SERPINI1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; PI12,serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; neuroserpin; Neuroserpin; NEUS_HUMAN; Peptidase inhibitor 12; PI-12; PI12; Protease inhibitor 12; Serin

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Pathway

Validated targets of C-MYC transcriptional activation, organism-specific biosystem;