Anti-SCD monoclonal antibody (CABT-38932MH)

Mouse anti-Human SCD monoclonal antibody for IHC-Fr, IHC-P, ICC/IF, FC, WB, IP, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
DE.F20
Species Reactivity
Mouse, Rat, Human
Immunogen
Recombinant full length protein (Human).
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 4μg/ml; Flow Cyt: 1μg/106 cells; WB: 1/1000;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SCD; stearoyl-CoA desaturase (delta-9-desaturase); SCDOS,stearoyl CoA desaturase opposite strand; acyl-CoA desaturase; acyl CoA desaturase; delta 9 desaturase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase)) is a Protein Coding gene. Diseases associated with SCD include carnitine deficiency, systemic primary and reye syndrome. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD5. This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3. 9 and 5. 2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.
Antigen Description
Stearoyl-CoA desaturase (SCD; EC 1. 14. 99. 5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Zhang et al. Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Stearoyl-CoA desaturase (Δ-9-desaturase) is a protein that in humans is encoded by the SCD gene. 19. 1) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids.
Pathway
Adipogenesis, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, conserved biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem; PPAR signaling pathway, conserved biosystem.

Citations


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References


Yu, HY; Pei, JH; et al. Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure. DISEASE MARKERS :-(2014).
LaSalle-Williams, M; Nuss, R; et al. Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center. TRANSFUSION 51:1732-1739(2011).

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