Anti-SAP 2a monoclonal antibody (DMAB7813MH)

Mouse anti-Human SAP 2a monoclonal antibody for ELISA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
21C12
Species Reactivity
Human
Immunogen
a synthetic peptide corresponding to amino acids near the N-terminus of human p38/SAPK2α, conjugated to KLH.
Conjugate
Unconjugated

Target


Alternative Names
CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein

Product Background


Antigen Description
p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation and apoptosis. p38 MAP Kinase (MAPK), also called RK or CSBP, is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signalling cascade controlling cellular responses to cytokines and stress. Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cyto.

Citations


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References


Barancik, M; Htun, P; et al. Okadaic acid and anisomycin are protective and stimulate the SAP/JNK pathway. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 34:182-190(1999).
Stefansson, B; Brautigan, DL; et al. Protein phosphatase 6 subunit with conserved sit4-associated protein domain targets I kappa B epsilon. JOURNAL OF BIOLOGICAL CHEMISTRY 281:22624-22634(2006).

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