Anti-RORA monoclonal antibody (DMABT-H27443H)

Mouse anti-Human RORA monoclonal antibody for ELISA, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
I4036
Species Reactivity
Human
Immunogen
BALB/c mouse ascites inoculated with hybridoma of spleen cells of BALB/c mouse immunized with recombinant human ROR alpha (136-236 aa) and mouse myeloma cells (NS-1)
Conjugate
Unconjugated

Target


Alternative Names
RORA; RAR-related orphan receptor A; nuclear receptor ROR-alpha; NR1F1; ROR1; ROR2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RORA (RAR Related Orphan Receptor A) is a Protein Coding gene. Diseases associated with RORA include post-traumatic stress disorder and hypoalphalipoproteinemia. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is NR1D2. The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene.
Pathway
Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Circadian rhythm - mammal, organism-specific biosystem; Circadian rhythm - mammal, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem.

Citations


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References


Baumjohann, D; Kageyama, R; et al. The microRNA cluster miR-17 similar to 92 promotes T-FH cell differentiation and represses subset-inappropriate gene expression. NATURE IMMUNOLOGY 14:840-+(2013).
Ino, H; et al. Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 52:311-323(2004).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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