Anti-RORA monoclonal antibody (DMABT-H27443H)
Mouse anti-Human RORA monoclonal antibody for ELISA, WB, IHC
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BALB/c mouse ascites inoculated with hybridoma of spleen cells of BALB/c mouse immunized with recombinant human ROR alpha (136-236 aa) and mouse myeloma cells (NS-1)
RORA; RAR-related orphan receptor A; nuclear receptor ROR-alpha; NR1F1; ROR1; ROR2
RORA (RAR Related Orphan Receptor A) is a Protein Coding gene. Diseases associated with RORA include post-traumatic stress disorder and hypoalphalipoproteinemia. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is NR1D2. The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene.
Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Circadian rhythm - mammal, organism-specific biosystem; Circadian rhythm - mammal, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem.
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Baumjohann, D; Kageyama, R; et al. The microRNA cluster miR-17 similar to 92 promotes T-FH cell differentiation and represses subset-inappropriate gene expression. NATURE IMMUNOLOGY 14:840-+(2013).
Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.