Anti-PMEPA1 monoclonal antibody (CABT-37360MH)

Mouse anti-Human PMEPA1 monoclonal antibody for WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
EML1688
Species Reactivity
Human
Immunogen
Recombinant fragment: NRTIFDSDLM DSARLGGPCP PSSNSGISAT CYGSGGRMEG PPPTYSEVIG HYPGSSFQHQ QSSGPPSLLE GTRLHHTHIA PLESAAIWSK EKDKQKGHPL , corresponding to amino acids 181-281 of Human TMEPAI
Conjugate
Unconjugated

Applications


Application Notes
WB: 1-5 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PMEPA1; prostate transmembrane protein, androgen induced 1; TMEPAI,transmembrane, prostate androgen induced RNA; transmembrane prostate androgen-induced protein; solid tumor associated 1; STAG1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include WW domain binding and R-SMAD binding. An important paralog of this gene is LDLRAD4. This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene. Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). 0The function about PMEPA1 antigen include WW domain binding; molecular_function.

Citations


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