Anti-PLA2G10 monoclonal antibody (CABT-31320RH)
Rabbit Anti-Human PLA2G10 Polyclonal antibody for ELISA, WB
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Recombinant human Phospholipase A2 X. A 15.5 kDa protein containing 123 amino acid residues of the human Phospholipase A2 X and 16 additional amino acid residues, HisTag. Source of immunogen, E.coli
WB: 1 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
PLA2G10; phospholipase A2, group X; group 10 secretory phospholipase A2; GXPLA2; Group X secretory phospholipase A2; GXPLA2
PLA2G10 (Phospholipase A2 Group X) is a Protein Coding gene. Diseases associated with PLA2G10 include acute chest syndrome and potters syndrome. Among its related pathways are Metabolism and Fat digestion and absorption. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G2C. This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism.
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. Group 10 secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G10 gene. 0The function about PLA2G10 antigen include calcium ion binding; hydrolase activity; phospholipase A2 activity; phospholipase activity.
Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic sy.
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Hanasaki, K; Ono, T; et al. Purified group X secretory phospholipase A(2) induced prominent release of arachidonic acid from human myeloid leukemia cells. JOURNAL OF BIOLOGICAL CHEMISTRY 274:34203-34211(1999).
AKIBA, S; SATO, T; et al. EVIDENCE FOR AN INCREASE IN THE ASSOCIATION OF CYTOSOLIC PHOSPHOLIPASE-A(2) WITH THE CYTOSKELETON OF STIMULATED RABBIT PLATELETS. JOURNAL OF BIOCHEMISTRY 113:4-6(1993).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.