Anti-NR2F1 monoclonal antibody (DMABT-H27458H)

Mouse anti-Human NR2F1 monoclonal antibody for WB, ELISA, IP, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
I9243
Species Reactivity
Human
Immunogen
BALB/c mouse ascites inoculated with hybridoma spleen cells of BALB/c mouse immunized with recomb. human COUP-TF I (6-81 aa) and mouse myeloma cells (NS-1)
Conjugate
Unconjugated

Target


Alternative Names
NR2F1; nuclear receptor subfamily 2, group F, member 1; ERBAL3, TFCOUP1; COUP transcription factor 1; COUP TFI; EAR 3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1) is a Protein Coding gene. Diseases associated with NR2F1 include bosch-boonstra-schaaf optic atrophy syndrome and optic atrophy-intellectual disability syndrome. Among its related pathways are Gene Expression and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is RXRG. The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS).
Antigen Description
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) [MIM:615722]: An autosomal dominant disorder characterized by optic atrophy associated with developmental delay and intellectual disability. Most patients also have evidence of cerebral visual impairment. Note=The disease is caused by mutations affecting the gene represented in this entry. COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors. Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5-AGGTCA-3 motif. The function about NR2F1 antigen include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid horm.
Pathway
Adipogenesis, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem.

Citations


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References


Simon, L; Spiewak, KA; et al. Stromal Progesterone Receptors Mediate Induction of Indian Hedgehog (IHH) in Uterine Epithelium and Its Downstream Targets in Uterine Stroma. ENDOCRINOLOGY 150:3871-3876(2009).
Chiang, DY; Cuthbertson, DW; et al. A Coregulatory Network of NR2F1 and microRNA-140. PLOS ONE 8:-(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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