Anti-RPS6KA4 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide.

Conjugate

Alternative Names

RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; ribosomal protein S6 kinase alpha-4; MSK2; RSK B; 90 kDa ribosomal protein S6 kinase 4; EC 2.7.11.1; Mitogen and stress activated protein kinase 2; Nuclear mitogen and stress activated protein ki

Entrez Gene ID

UniProt ID

Antigen Description

Mitogen- and stress-activated protein kinases (MSK2) is nuclear kinase that act downstream of mitogen-activated protein/extracellular signal-regulated kinase pathways. It contains two kinase domains in the N-terminal and C-terminal region, respectively. MSK2 is activated in response to mitogenic stimuli via Erk1/2MAPK pathway and also by stress stimuli via p38MAPK pathway. Signals from mitogens and cellular stresses are involved in many functions including cell proliferation, differentiation, and survival through the phosphorylation of cyclic AMP response element-binding protein (CREB) at Ser133 which is catalyzed by MSK2. Recently, MSK2 has been shown to be required for stress-induced phosphorylation of histone H3-Ser and transcriptional activation of several immediate early genes.

Pathway

Axon guidance; ErbB1 downstream signaling; Insulin Signaling; L1CAM interactions; MAPK signaling pathway; Neurotrophin signaling pathway; Recycling pathway of L1; Signal transduction by L1; Signaling mediated by p38-alpha and p38-beta.