Anti-MST1R monoclonal antibody (CABT-31516MH)

Mouse anti-Human MST1R monoclonal antibody for Neut Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
NN0589-20G35
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to the extracellular domain of Human RON
Conjugate
Unconjugated

Target


Alternative Names
MST1R; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); PTK8,PTK8 protein tyrosine kinase 8 , RON; macrophage-stimulating protein receptor; CD136; CDw136
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MST1R (Macrophage Stimulating 1 Receptor) is a Protein Coding gene. Diseases associated with MST1R include renal oncocytoma and breast cancer. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RYK. This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Antigen Description
This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Transcript variants have been described, but it is not known whether these transcripts are normally produced. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON (Recepteur dOrigine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase. 0The function about MST1R antigen include ATP binding; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein binding; receptor activity.
Pathway
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; a6b1 and a6b4 Integrin signaling, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem.

Citations


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References


Catenacci, DVT; Cervantes, G; et al. RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. CANCER BIOLOGY & THERAPY 12:9-46(2011).
Gruver, AM; Liu, L; et al. Immunohistochemical application of a highly sensitive and specific murine monoclonal antibody recognising the extracellular domain of the human hepatocyte growth factor receptor (MET). HISTOPATHOLOGY 65:879-896(2014).

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