MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), also known as MLH1, is a human gene located on Chromosome 3. t is a gene commonly associated with hereditary nonpolyposis colorectal cancer. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
Pathway
BRCA1-associated genome surveillance complex (BASC); Fanconi anemia pathway; Meiosis; Colorectal cancer; Direct p53 effectors; Endometrial cancer; Meiotic Recombination; Mismatch repair; Ovarian Infertility Genes; Pathways in cancer
Citations
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