Anti-MECP2 monoclonal antibody (CABT-34739MH)

Mouse anti-Human MECP2 monoclonal antibody for IHC-P, WB Datasheet

Bring this labeled antibody directly to your bench!

Online Inquiry Add to basket

Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
EML586
Species Reactivity
Human
Immunogen
Recombinant fragment: PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ , corresponding to amino acids 81-170 of Human MeCP2
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 - 5 μg/ml; IHC-P: 3 μg/ml.Flow Cyt: 0.5μg/106 cells.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MECP2; methyl CpG binding protein 2 (Rett syndrome); mental retardation, X linked 16 ,mental retardation, X linked 79 , MRX16, MRX79, RTT; methyl-CpG-binding protein 2; AUTSX 3; AUTSX3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MECP2 (Methyl-CpG Binding Protein 2) is a Protein Coding gene. Diseases associated with MECP2 include rett syndrome and mental retardation, x-linked, syndromic 13. Among its related pathways are SIDS Susceptibility Pathways and Macrophage Differentiation and Growth Inhibition by METS. GO annotations related to this gene include poly(A) RNA binding and chromatin binding. An important paralog of this gene is MBD4. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

Citations


Have you cited CABT-34739MH in a publication? Let us know and earn a reward for your research.

References


Jost, KL; Rottach, A; et al. Generation and Characterization of Rat and Mouse Monoclonal Antibodies Specific for MeCP2 and Their Use in X-Inactivation Studies. PLOS ONE 6:-(2011).
Ronnett, GV; Leopold, D; et al. Olfactory biopsies demonstrate a defect in neuronal development in Rett's syndrome. ANNALS OF NEUROLOGY 54:206-218(2003).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-MECP2 monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket