Anti-MDM4 Monoclonal antibody, clone NENY-93

Antibody Isotype

IgG1

Clone

NENY-93

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide: KDPSPLYDMLRKNL, corresponding to amino acids 93-106 of Human MDMX.

Conjugate

Application Notes

WB: 1 - 2μg/ml

Alternative Names

MDM4; Mdm4 p53 binding protein homolog (mouse); Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) ,mouse double minute 4, human homolog of; p53 binding protein; protein Mdm4; MDMX; DKFZp781B1423; Double minute 4; Double minute 4 huma

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latters degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Pathway

p53 pathway, organism-specific biosystem; p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem;