Rabbit Anti-Human MDC1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human Mediator of DNA-damage checkpoint 1

Conjugate

Application Notes

IHC: 1:100-1:300

General Notes

This product (Catalog No. CPBT-38860RH) is a rabbit-derived IgG polyclonal antibody raised against human MDC1. It has been affinity purified by protein A. The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
CPBT-38860RH is suitable for use in IHC (1:100–1:300) application.
CPBT-38860RH is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

NFBD1

Entrez Gene ID

UniProt ID