Anti-LSAMP monoclonal antibody (CABT-34348MH)

Mouse anti-Human LSAMP monoclonal antibody for WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
NN0556-4I55
Species Reactivity
Human
Immunogen
Recombinant full length Human LSAMP.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/1000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
LSAMP; limbic system-associated membrane protein; IgLON family member 3; IGLON3; LAMP; IgLON family member 3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
LSAMP (Limbic System-Associated Membrane Protein) is a Protein Coding gene. An important paralog of this gene is NTM. This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Antigen Description
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity). The function about LSAMP antigen include protein binding.

Citations


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References


Innos, J; Koido, K; et al. Limbic system-associated membrane protein as a potential target for neuropsychiatric disorders. FRONTIERS IN PHARMACOLOGY 4:-(2013).

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