Mouse anti-Human LAMA5 monoclonal antibody for WB
LAMA5 (Laminin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with LAMA5 include galloway-mowat syndrome and alport syndrome. Among its related pathways are Degradation of the extracellular matrix and Metabolism. GO annotations related to this gene include receptor binding and integrin binding. An important paralog of this gene is LAMC2. This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).
IL1F6 is a member of the interleukin 1 cytokine family. It has a conserved 12-stranded beta-trefoil structure. Binding analysis failed to detect interaction with multiple IL1R family members. Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin subunit alpha-5 is a protein that in humans is encoded by the LAMA5 gene. Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. The function about LAMA5 antigen include binding; integrin binding; structural molecule activity.
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Inflammatory Response Pathway, organism-specific biosystem; Integrin cell surface interactions, organism-specific biosystem; Pa.
Fukumoto, S; Miner, JH; et al. Laminin alpha 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. JOURNAL OF BIOLOGICAL CHEMISTRY 281:5008-5016(2006).
Kikkawa, Y; Virtanen, I; et al. Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha 5 in the glomerular basement membrane. JOURNAL OF CELL BIOLOGY 161:187-196(2003).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.