Anti-Keratan Sulphate monoclonal antibody (DMAB8403)

Mouse anti-Human Keratan Sulphate monoclonal antibody for ELISA, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG
Clone
6E5
Species Reactivity
Human
Immunogen
Keratan sulphate from skeletal KS type II in human aggrecan.
Conjugate
Unconjugated

Target


Alternative Names
Carbohydrate chondroitin 6 keratan sulfotransferase 1; Carbohydrate chondroitin 6 keratan sulfotransferase; Carbohydrate keratan sulfate Gal 6 sulfotransferase; Carbohydrate keratan sulfate Gal 6 sulfotransferase 1; Carbohydrate sulfotransferase 1; CHST1

Product Background


Antigen Description
Keratan Sulphate (KS) is sulphated glycosoaminoglycan (GAG) component of proteoglycans found in cornea (KS type I), cartilage, intervertebral disk and other musculoskeletal tissues (KS type II). The KS chains are attached to the core proteins of many matrix proteoglycans eg lumican, keratocan, aggrecan etc. This monoclonal antibody has been raised against skeletal KS type II in human aggrecan. In addition to recognising skeletal KS type II epitopes it recognises corneal KS type I.

Citations


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References


Resch, MD; Nagy, ZZ; et al. Spatial distribution of keratan sulfate in the rabbit cornea following photorefractive keratectomy. JOURNAL OF REFRACTIVE SURGERY 21:485-493(2005).
Ho, LTY; Harris, AM; et al. A comparison of glycosaminoglycan distributions, keratan sulphate sulphation patterns and collagen fibril architecture from central to peripheral regions of the bovine cornea. MATRIX BIOLOGY 38:59-68(2014).

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