General Notes
This product (Catalog No. CPBT-55106RH) is a rabbit-derived polyclonal antibody raised against human KRAS, targeting the amino acid region 1–149 of the protein. This antibody exhibits cross-reactivity with Human KRAS from mouse and rat. It has been affinity purified by Protein A. KRAS, also known as the KRAS proto-oncogene, GTPase, is a gene located on the short arm of human chromosome 12 at position 12p12.1 that encodes a small GTPase protein belonging to the RAS family of oncogenes. This protein, known as K-Ras, functions as a molecular switch in intracellular signaling pathways, cycling between an active GTP-bound state and an inactive GDP-bound state to regulate critical cellular processes such as proliferation, differentiation, and survival, primarily through the RAS/MAPK signaling cascade. In normal cells, KRAS relays extracellular signals from growth factor receptors to the nucleus, ensuring controlled cell growth; however, it is one of three RAS genes (alongside HRAS and NRAS) frequently implicated in oncogenesis due to its central role in signal transduction.
CPBT-55106RH is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
CPBT-55106RH is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
COA
Publication 
Loading ......
