Fertility evaluation in adults with perinatally acquired HIV-1 infection: a cross-sectional observational study
HIV MEDICINE
Authors: Pasvol, T.; Teh, J.; Balfoussia, D.; Ayres, S.; Hall, R.; Petersen, C.; Khan, M.; Lovell, A.; Jayasena, C.; Foster, C.; Fidler, S.
Abstract
A facile synthesis of 6-[(4-nitrophenyl)thio]-substituted 2-methylene-2,3-dihydro-1,4-oxazepines from N-propargylic beta-enaminones
SYNTHETIC COMMUNICATIONS
Authors: Kelgokmen, Yilmaz; Korkmaz, Esra; Zora, Metin
Abstract
A one-pot process for the synthesis of 6-[(4-nitrophenyl)thio]-substituted 2-methylene-2,3-dihydro-1,4-oxazepines is reported. When reacted with 4-nitrobenzenesulfenyl chloride, N-propargylic beta-enaminones afforded alpha-sulfenylated N-propargylic beta-enaminones, which, in the presence of zinc chloride, underwent electrophilic cyclization to yield 6-[(4-nitrophenyl)thio]-substituted 2-methylene-2,3-dihydro-1,4-oxazepines. Process was found to be general for various N-propargylic beta-enaminones along with large substrate scope and high functional group tolerance. This operationally easy method may provide quick access to a library of functionalized 1,4-oxazepines of pharmacological interest.
COA
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