Anti-GOLGA2 monoclonal antibody (CABT-38732RH)

Rabbit anti-Human GOLGA2 monoclonal antibody for ICC/IF, IHC-P, IHC-Fr, WB, IP Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
AG002
Species Reactivity
Mouse, Rat, Cow, Dog, Human, Monkey, African green monkey
Immunogen
A synthetic peptide corresponding to residues near the N-term of human GM130.
Conjugate
Unconjugated

Applications


Application Notes
ICC/IF: 1/100 - 1/250; IHC-P: 1/250 - 1/500; WB: 1/1000 - 1/10000; IP: 1/50.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
GOLGA2; golgin A2; golgi autoantigen, golgin subfamily a, 2; Golgin subfamily A member 2; GM130; Golgi matrix protein GM130
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GOLGA2 (Golgin A2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitotic Prophase. GO annotations related to this gene include protein kinase binding and syntaxin binding. An important paralog of this gene is GOLGA8G. The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.
Antigen Description
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane.Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940).TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). Golgin subfamily A member 2 is a protein that in humans is encoded by the GOLGA2 gene. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. The function about GOLGA2 antigen include protein binding.
Pathway
PLK1 signaling events, organism-specific biosystem.

Citations


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References


Fuller, SJ; McGuffin, LJ; et al. A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3). BIOCHEMICAL JOURNAL 442:595-610(2012).
Sugden, PH; McGuffin, LJ; et al. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. BIOCHEMICAL JOURNAL 454:13-30(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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