Anti-EPOR Monoclonal antibody, clone NN-0042-7H8

Antibody Isotype

IgG2a

Clone

NN-0042-7H8

Species Reactivity

Human

Immunogen

Human recombinant EPO Receptor (extracellular domain)

Conjugate

Application Notes

IHC-P: 1/10 - 1/40; WB 1/1000 - 1/2000; Flow Cyt: 1μg/10⁶ cells

Alternative Names

EPOR; erythropoietin receptor; EPO R; EPO-R; epor; EPOR_HUMAN; Erythropoietin receptor; Erythropoietin receptor precursor; EPO-R;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described.

Pathway

Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Kit Receptor Signaling Pathway, organism-specific bio