Anti-CSTA monoclonal antibody (DMAB5501MH)

Mouse anti-Human CSTA monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
XT-24/3/4/4
Species Reactivity
Human
Immunogen
Human Cystatin A
Conjugate
Unconjugated

Target


Alternative Names
CSTA; cystatin A (stefin A); AREI; STF1; STFA; cystatin-A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CSTA (Cystatin A) is a Protein Coding gene. Diseases associated with CSTA include exfoliative ichthyosis, autosomal recessive, ichthyosis bullosa of siemens-like and exfoliative ichthyosis. GO annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is CSTB. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
Antigen Description
Cystatin-A is a protein that in humans is encoded by the CSTA gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. Peeling skin syndrome 4 (PSS4) [MIM:607936]: A genodermatosis characterized by congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. PSS4 presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes. Note=The disease is caused by mutations affecting the gene represented in this entry. 0The function about CSTA antigen include cysteine-type endopeptidase inhibitor activity; protease binding; protein binding, bridging; structural molecule activity.

Citations


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References


Duthy, TG; Manning, PA; et al. Identification and characterization of assembly proteins of CS5 pili from enterotoxigenic Escherichia coli. JOURNAL OF BACTERIOLOGY 184:1065-1077(2002).
Rasmussen, JJ; Vegge, CS; et al. Campylobacter jejuni carbon starvation protein A (CstA) is involved in peptide utilization, motility and agglutination, and has a role in stimulation of dendritic cells. JOURNAL OF MEDICAL MICROBIOLOGY 62:1135-1143(2013).

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