Anti-CCND2 monoclonal antibody (DMAB5374MH)

Mouse anti-Human CCND2 monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
EDT-3.2
Species Reactivity
Human
Immunogen
Prokaryotic recombinant protein corresponding to full length cyclin D2.
Conjugate
Unconjugated

Target


Alternative Names
CCND2; cyclin D2; KIAK0002; G1/S-specific cyclin-D2; G1/S-specific cyclin D2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CCND2 (Cyclin D2) is a Protein Coding gene. Diseases associated with CCND2 include megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 and megalencephaly. Among its related pathways are Cell Cycle, Mitotic and MicroRNAs in cancer. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
Antigen Description
G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) [MIM:615938]: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. The function about CCND2 antigen include protein kinase binding.
Pathway
B Cell Receptor Signaling Pathway; Cell Cycle; Cyclin D associated events in G1; Focal Adhesion; G1 Phase; HTLV-I infection; IL-7 Signaling Pathway; Jak-STAT signaling pathway; Measles; Transcriptional misregulation in cancers; Wnt Signaling Pathway and P.

Citations


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References


Metcalf, RA; Zhao, SC; et al. Characterization of D-cyclin proteins in hematolymphoid neoplasms: lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes. MODERN PATHOLOGY 23:420-433(2010).
Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

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