Anti-CUL3 monoclonal antibody (CABT-38400RH)
Rabbit anti-Human CUL3 monoclonal antibody for WB, IP, FC
Datasheet
Specifications
Host Species
Rabbit
Antibody Isotype
IgG1
Clone
FQ3429Z
Species Reactivity
Mouse, Rat, Human
Immunogen
Synthetic peptide corresponding to residues in Human Cullin 3.
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/1000 - 1/5000; IP: 1/50; Flow Cyt: 1/50;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Target
Alternative Names
CUL3; cullin 3; cullin-3; CUL 3; Cul-3; cul3
Entrez Gene ID
UniProt ID
Product Background
Gene summary
CUL3 (Cullin 3) is a Protein Coding gene. Diseases associated with CUL3 include pseudohypoaldosteronism, type iie and pseudohypoaldosteronism, type iia. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity. An important paralog of this gene is CUL1. This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division (Sumara et al. , 2007Pseudohypoaldosteronism 2E (PHA2E) [MIM:614496]: An autosomal dominant disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. Note=The disease is caused by mutations affecting the gene represented in this entry. Cullin-3 is a protein that in humans is encoded by the CUL3 gene. 0The function about CUL3 antigen include cyclin binding; protein binding; ubiquitin protein ligase binding; contributes_to ubiquitin-protein ligase activity.
Pathway
ATF-2 transcription factor network, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Cul3-SPOP complex, organism-specific biosystem; Immune System, organism-specific biosyst.
Citations
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References
Watai, Y; Kobayashi, A; et al. Subcellular localization and cytoplasmic complex status of endogenous Keap1. GENES TO CELLS 12:1163-1178(2007).
Lugade, AA; Vethanayagam, RR; et al. Nrf2 Regulates Chronic Lung Inflammation and B-Cell Responses to Nontypeable Haemophilus influenzae. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 45:557-565(2011).
Related Products
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Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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