Anti-CLDN1 monoclonal antibody (CABT-30412RH)

Rabbit anti-Human CLDN1 monoclonal antibody for IHC-P Datasheet

Bring this labeled antibody directly to your bench!

Online Inquiry Add to basket

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
TQ239
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to C-terminus of Human Claudin 1.
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/200; Flow Cyt: 1/100.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Human hepatocellular carcinoma stained with anti-claudin-1 antibody
Flow cytometric analysis of rabbit anti-Claudin-1 antibody in HEPG2 (green) compare to negative control of rabbit IgG (blue)

Target


Alternative Names
CLDN1; claudin 1; claudin-1; ILVASC; SEMP1; senescence associated epithelial membrane protein 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLDN1 (Claudin 1) is a Protein Coding gene. Diseases associated with CLDN1 include ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis and ichthyosis-hypotrichosis-sclerosing cholangitis syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Antigen Description
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. The function about CLDN1 antigen include identical protein binding; structural molecule activity.
Pathway
Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; Nectin adhe.

Citations


Have you cited CABT-30412RH in a publication? Let us know and earn a reward for your research.

References


Harris, HJ; Farquhar, MJ; et al. CD81 and claudin 1 coreceptor association: Role in hepatitis C virus entry. JOURNAL OF VIROLOGY 82:5007-5020(2008).
Arabzadeh, A; Troy, TC; et al. Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis. BMC CANCER 7:-(2007).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-CLDN1 monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket