Anti-CGB5 monoclonal antibody (CABT-32595RH)

Rabbit anti-Human CGB5 monoclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS4487
Species Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues in Human CGB5.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CGB5; chorionic gonadotropin, beta polypeptide 5; HCG; CG beta; CGB3; Chorionic gonadotrophin chain beta
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CGB5 (Chorionic Gonadotropin Beta Subunit 5) is a Protein Coding gene. Diseases associated with CGB5 include gestational trophoblastic tumor and invasive mole. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism. GO annotations related to this gene include hormone activity. An important paralog of this gene is TSHB. This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13. 3 and contiguous with the luteinizing hormone beta subunit gene.
Antigen Description
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5 untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Pathway
Glycoprotein hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Peptide hormone biosynthesis, organism-specific biosystem.

Citations


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References


Zimmermann, G; Ackermann, W; et al. Expression and Production of Human Chorionic Gonadotropin (hCG) in the Normal Secretory Endometrium: Evidence of CGB7 and/or CGB6 Beta hCG Subunit Gene Expression. BIOLOGY OF REPRODUCTION 86:-(2012).
Delville, M; Sigdel, TK; et al. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. SCIENCE TRANSLATIONAL MEDICINE 6:-(2014).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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