Anti-CD99 monoclonal antibody (DMAB5406MH)

Mouse anti-Human CD99 monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgM
Clone
IP37-1.2
Species Reactivity
Human
Immunogen
BALB/C mice were injected with purified E-rosette forming cells from human peripheral blood lymphocytes.
Conjugate
Unconjugated

Target


Alternative Names
CD99; CD99 molecule; MIC2; HBA71; MIC2X; MIC2Y
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CD99 (CD99 Molecule) is a Protein Coding gene. Diseases associated with CD99 include extraosseous ewings sarcoma and ewing sarcoma. Among its related pathways are Integrin Pathway and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus.
Antigen Description
CD99 antigen (Cluster of differentiation 99) also known as MIC2 or single-chain type-1 glycoprotein is a protein that in humans is encoded by the CD99 gene. The protein has a mass of 32 kD. Although present on the X chromosome, unusually, the CD99 gene does not undergo X inactivation, and it was the first such pseudo-autosomal gene to be discovered in humans. Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. Unusually for a gene present on the X chromosome, the CD99 gene does not undergo X inactivation, and it was the first such pseudoautosomal gene to be discovered in humans.
Pathway
Cell adhesion molecules (CAMs); Leukocyte transendothelial migration.

Citations


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References


DEITOS, AP; WADDEN, C; et al. IMMUNOHISTOCHEMICAL DEMONSTRATION OF GLYCOPROTEIN P30/32(MIC2) (CD99) IN SYNOVIAL SARCOMA - A POTENTIAL CAUSE OF DIAGNOSTIC CONFUSION. APPLIED IMMUNOHISTOCHEMISTRY 3:168-173(1995).
Gautam, U; Srinivasan, R; et al. Comparative Evaluation of Flow-Cytometric Immunophenotyping and Immunocytochemistry in the Categorization of Malignant Small Round Cell Tumors in Fine-Needle Aspiration Cytologic Specimens. CANCER CYTOPATHOLOGY 114:494-503(2008).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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