Anti-CD99 monoclonal antibody (DMAB5406MH)

Mouse anti-Human CD99 monoclonal antibody for IHC Datasheet

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Host Species
Antibody Isotype
Species Reactivity
BALB/C mice were injected with purified E-rosette forming cells from human peripheral blood lymphocytes.


Alternative Names
CD99; CD99 molecule; MIC2; HBA71; MIC2X; MIC2Y
Entrez Gene ID
UniProt ID

Product Background

Gene summary
CD99 (CD99 Molecule) is a Protein Coding gene. Diseases associated with CD99 include extraosseous ewings sarcoma and ewing sarcoma. Among its related pathways are Integrin Pathway and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus.
Antigen Description
CD99 antigen (Cluster of differentiation 99) also known as MIC2 or single-chain type-1 glycoprotein is a protein that in humans is encoded by the CD99 gene. The protein has a mass of 32 kD. Although present on the X chromosome, unusually, the CD99 gene does not undergo X inactivation, and it was the first such pseudo-autosomal gene to be discovered in humans. Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. Unusually for a gene present on the X chromosome, the CD99 gene does not undergo X inactivation, and it was the first such pseudoautosomal gene to be discovered in humans.
Cell adhesion molecules (CAMs); Leukocyte transendothelial migration.


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McCluggage, WG; Maxwell, P; et al. Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord-stromal tumours. HISTOPATHOLOGY 38:403-408(2001).
Monteagudo, C; Calduch, L; et al. CD99 immunoreactivity in atypical fibroxanthoma - A common feature of diagnostic value. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 117:126-131(2002).

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