Anti-CAMKK1 monoclonal antibody (CABT-32022MH)

Mouse anti-Human CAMKK1 monoclonal antibody for IHC-P, WB, sELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2G7
Species Reactivity
Human
Immunogen
Recombinant Human CaMKK protein .
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/1000; IHC-P: 5 μg/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CAMKK1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; calcium/calmodulin-dependent protein kinase kinase 1; CAMKKA; DKFZp761M0423; MGC34095
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CAMKK1 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and AMPK signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK11. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.
Antigen Description
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. 0The function about CAMKK1 antigen include ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; nucleotide binding.
Pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; CREB phosphorylation through the activation of CaMKK, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Receptor Binding And Downstream Transmission In ThePostsynaptic Cell, organism-specific biosystem; Post NMDA receptor activation even.

Citations


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References


OKAYAMA, N; ITOH, M; et al. MEDIATION OF PEPSINOGEN SECRETION FROM GUINEA-PIG CHIEF CELLS BY CA2+ CALMODULIN-DEPENDENT PROTEIN-KINASE-II. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1268:123-129(1995).
Boudreau, AC; Ferrario, CR; et al. Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. JOURNAL OF NEUROCHEMISTRY 110:363-377(2009).

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