Anti-Butyrophilin monoclonal antibody (DMAB6451)

Mouse anti-Bovine Butyrophilin monoclonal antibody for WB, IHC-Fr Datasheet

Online Inquiry Add to basket   


Host Species
Antibody Isotype
Species Reactivity
Butyrophilin purified from bovine milk fat globule membrane


Alternative Names
Btn; Butyrophilin; BT1A1_HUMAN; BTN; Btn1a1; butyrophilin

Product Background

Gene summary
BTN1A1 (Butyrophilin Subfamily 1 Member A1) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. GO annotations related to this gene include receptor activity. An important paralog of this gene is BTNL8. Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function.
Antigen Description
May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Butyrophilin subfamily 1 member A1 is a protein that in humans is encoded by the BTN1A1 gene. Btn1a1 regulates the amount of lipids and size of droplets expressed in milk. When the gene is compromised in laboratory mice, approximately half the pups died within the first 20 days and the remainder were significantly under-weight. Butyrophilin (Btn) genes constitute a subgroup of at least 10 genes in the Ig superfamily identified in human, mouse, cow, goat and other species. The eponymous Btn gene (BTN1A1 in humans; Btn1a1 in mouse) is highly expressed in the secretory epithelium of the mammary gland during lactation. Other homologues are predominantly expressed in skeletal muscle and the intestine and erythroid cells. In contrast, BTN2A1 and 2 and BTN3A1, 2, and 3 are widely expressed in many tissues, suggesting that the structural domains of Btn proteins may have both universal and tissue-specific functions.


Have you cited DMAB6451 in a publication? Let us know and earn a reward for your research.


Messal, N; Mamessier, E; et al. Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. EUROPEAN JOURNAL OF IMMUNOLOGY 41:3443-3454(2011).

Custom Antibody Labeling

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews

Write a review, share your experiences with others and get rewarded !

Online Inquiry

Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-Butyrophilin monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket